Library/For Long/NAD+

OTC (precursors)For LongMost-studied longevity molecule+1 more★ Popular

NAD+

Nicotinamide adenine dinucleotide. We read all 60 studies. The protocol is below.

Updated 19 May 2026Read 13 minEvidence ●●●○○Citations 60

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The NAD+ Report · $19

Everything you need to start: dose, sourcing, safety, our verdict.

One purchase · yours forever

Built from 60 cited studies.

Status

OTC

Class

For Long

Evidence

3/ 5●●●○○

Best-evidenced oral dose

$19 ↓

Human trials (NR + NMN)

$19 ↓

Raises blood NAD+

$19 ↓

Read this if

you've been quoted $300 for an IV drip and want to know if it does anything — **the trial-grade oral dose is NR 250–1000 mg/day for 8–12 weeks** (Martens 2018 PMID 29602900); the loading-drip frame is marketing
you read Sinclair, watch Bryan Johnson, and want the honest read on **NMN vs NR — NR is still legally a supplement in the US; NMN was reclassified by FDA as a drug in 2022** and the comparative-absorption data doesn't show NMN winning
you're hungover and considering "the drip"

Skip this if

you want a peptide — this isn't one (it's a cofactor)
you expect the IV to do more than the oral precursors per dollar — the math says otherwise
you have active malignancy — NAD+ pathways feed cancer-cell metabolism in ways nobody is sure about

The 4 ways you can buy NAD+

No FDA-approved injectable NAD+. Oral NR / NMN are a different molecule sold OTC as supplements — …

Compounded 503A

✓

$200–$1,500/mo depending on route

Mid for tele-clinic subq; markup-heavy for IV-drip 'loading' protocols (no clinical evidence for 5…

RUO (research-only)

✓

Sold 'for research only'

$60–$200/mo (community dose patterns vary widely)

Pre-mixed product older than 30 days is sub-potent (NAD+ degrades in solution).

Gray market

✓

Unregulated overseas import

Varies — not on user's gray-vendor list 2026

Unverified. NAD+ degrades quickly in solution and isn't a common gray-market commodity at injectio…

Click any lane for the full Sourcing breakdown. Prices and lane availability vary by molecule — this is the per-peptide snapshot, not a generic table.

First 90 days · NAD+

What we'd actually do

Weeks 1–2

Nothing perceptible. Longevity peptides are not 'feel something' molecules. If a vendor says you'll notice an effect this fast, they're selling you on placebo.

Weeks 4–8

Possibly subtle shifts in biomarkers (inflammation, sleep, recovery). Subjective changes in this window are usually placebo and confounded with whatever else you changed.

Week 12 — decide

Bloodwork or biomarker check. If the protocol can't be defended on a labeled change at 12 weeks, it can't be defended on hope.

Quit if

Any unusual symptoms — especially the cancer-mechanism flag for angiogenic peptides.
12 weeks of continuous use with no objective biomarker support to keep going.
Tolerance signal (the protocol needs escalating doses to feel the same).

Identity

What it is.

NAD+ is nicotinamide adenine dinucleotide — not a at all, but a coenzyme found in every cell you have. It moves electrons inside the mitochondria during energy production and powers the sirtuins and PARPs, two enzyme families that handle DNA repair and metabolic signaling.

NAD+ levels drop with age in most tissues that have been measured. That observation is the entire engine behind the longevity-supplement industry — IV NAD+ drips, NMN and NR precursor capsules, NAD+ injections, sublingual lozenges.

The IV form is the cultural flagship. Clinics charge $300–$1,500 per drip, often marketed as anti-aging, hangover recovery, or cognitive support. Oral precursors (NMN, NR) are sold as supplements under DSHEA. None of it is for an anti-aging indication, because no such indication exists at the FDA.

TL;DR

TL;DR. 30-second version.

The compressed verdict — what NAD+ actually is, what the human evidence shows, and the watch-for in three bullets. Locked.

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Mechanism

Mechanism.

Mechanism · in the NAD+ report

How the molecule actually works — receptor profile, downstream signaling, what to expect mechanistically.

Get the report · $19 ↓

Evidence

Evidence. What we actually know in humans.

Evidence · in the NAD+ report

The trial breakdown — phase, n, primary endpoint, who funded, what hit, what didn't.

Get the report · $19 ↓

Human-Evidence Factbox

Best-evidenced oral dose

$19 ↓

Human trials (NR + NMN)

$19 ↓

Raises blood NAD+

$19 ↓

Clear clinical endpoint hits

$19 ↓

Half-life (oral precursors)

$19 ↓

Subq injection-site burn

$19 ↓

IV 'loading dose' protocols

$19 ↓

WADA status

$19 ↓

FDA NMN status (2022)

$19 ↓

Dose

Dose. The actual protocol.

Dose · in the NAD+ report

The specific protocol — dose, titration schedule, cycle pattern, frequency, route.

We read 60 studies to write this report.

Get the report · $19 ↓

Sourcing

Sourcing. Where the cohort actually buys.

Sourcing · in the NAD+ report

Sourcing breakdown — vendor methodology, red flags, our published test results, COA checklist.

We read 60 studies to write this report.

Get the report · $19 ↓

Safety

Safety. Side effects.

Safety · in the NAD+ report

The watch-for list — contraindications, drug interactions, monitoring labs, when to stop.

Get the report · $19 ↓

Editorial Position

Editorial position.

Editorial Position · in the NAD+ report

Our editorial position — explicit yes / no / depends, with the reasoning behind it.

Get the report · $19 ↓

Citations

Citations.

+Show all 60 citations

The NAD+ Report · $19

Everything you need to start.

Dose, sourcing, safety, our verdict. One purchase. Yours forever.

Built from 60 cited studies.

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