Titration

Titration means starting at a low dose and stepping up over weeks until you reach the target dose. It's standard practice for GLP-1s to manage GI side effects: tirzepatide ladders 2.5 → 5 → 7.5 → 10 → 12.5 → 15 mg/wk over 20 weeks. Skipping titration usually means worse nausea, diarrhea, and discontinuation. The 'top dose' from a trial is rarely what you start at — always check whether the protocol includes a ladder.