Pulsatile dosing means delivering many small doses spread across hours or days, mimicking how the body naturally releases hormones. Bolus dosing means one larger dose at once. The distinction is critical for some peptides — gonadorelin (GnRH) given pulsatile via pump every 90 minutes stimulates the HPG axis; given as a bolus subq it can suppress the axis (the opposite of intended effect). Always check the trial protocol's delivery pattern, not just the dose.
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