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RUO · Research Use OnlyFor Wet+2 more

Kisspeptin-10

The peptide that turns on puberty. We read all 60 studies. The protocol is below.

Updated 03 May 2026Read 12 minEvidence ●●○○○Citations 60
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Free — puts Kisspeptin-10 on your decision board.

The Kisspeptin-10 Report · $19

Everything you need to start: dose, sourcing, safety, our verdict.

One purchase · yours forever

Built from 60 cited studies.

Status
Research-only
Class
For Wet
Evidence
2/ 5●●○○○
FDA-approved
$19 ↓
Imperial College RCTs
$19 ↓
Molecule being sold (RUO)
$19 ↓
Read this if
  • you've already tried gonadorelin and PT-141 and want to go further upstream
  • you're a libido-and-T cohort reader and want to understand how the HPG axis actually starts
  • your endocrinologist mentioned hypogonadotropic hypogonadism and you're researching ahead
Skip this if
  • you have a pituitary tumor or other HPG-axis pathology that hasn't been worked up
  • you have hormone-sensitive cancer
  • you want a libido peptide with FDA-approval-level evidence — that's PT-141, not this
The 4 ways you can buy Kisspeptin-10
Brand
✗
No FDA approval
Compounded 503A
✗
No 503A pathway
RUO (research-only)
✓
Sold for research only
$45–$60/mo
Dominant channel for this molecule.
Gray market
✓
Illegal to import for huma…
$3–$7/mo
No purity oversight; coordination via Discord/Telegram.
Click any lane for the full Sourcing breakdown.
First 90 days · Kisspeptin-10
Weeks 1–2
On-demand class — works in 30–60 min on the day of use or it doesn't. The PT-141 effect either shows up at the proper dose or it's the wrong molecule for you.
Weeks 4–8
Side-effect accumulation is the real watch-for: facial hyperpigmentation (MC1 receptor), nausea with repeated use, mood changes.
Week 12 — decide
Decide based on the on-demand response pattern, not a slow build-up. There is no slow build-up here.
Quit if
  • Facial or scalp hyperpigmentation that doesn't fade after stopping for 2–4 weeks.
  • Persistent nausea on repeated use.
  • Zero response to 2–3 attempts at proper dose (one of these — it's not for everyone).
Identity

What it is.

Kisspeptin-10 is the active 10-amino-acid fragment of kisspeptin, a neuropeptide encoded by the KISS1 gene.

It was identified as the master regulator of puberty when researchers found that loss-of-function mutations in the receptor (GPR54) cause failure to enter puberty. Without kisspeptin signaling, the entire reproductive axis stays offline.

It's been studied in academic medical settings for hypogonadism, infertility, and sexual desire research, particularly out of Imperial College London (Waljit Dhillo's group). It is *not* an drug. In the US it's sold strictly as a research chemical (RUO).

TL;DR

TL;DR. 30-second version.

The compressed verdict — what Kisspeptin-10 actually is, what the human evidence shows, and the watch-for in three bullets. Locked.

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Mechanism

Mechanism.

Mechanism · in the Kisspeptin-10 report

How the molecule actually works — receptor profile, downstream signaling, what to expect mechanistically.

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Evidence

Evidence. What we actually know in humans.

Evidence · in the Kisspeptin-10 report

The trial breakdown — phase, n, primary endpoint, who funded, what hit, what didn't.

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Human-Evidence Factbox
FDA-approved
$19 ↓
Imperial College RCTs
$19 ↓
Molecule being sold (RUO)
$19 ↓
Molecule in the headline IVF + HSDD trials
$19 ↓
KP-10 half-life
$19 ↓
Animal studies
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Year KISS1 → GnRH link found
$19 ↓
Major adverse events flagged
$19 ↓
Dose

Dose. The actual protocol.

Dose · in the Kisspeptin-10 report

The specific protocol — dose, titration schedule, cycle pattern, frequency, route.

We read 60 studies to write this report.
Get the report · $19 ↓
Sourcing

Sourcing. Where the cohort actually buys.

Sourcing · in the Kisspeptin-10 report

Sourcing breakdown — vendor methodology, red flags, our published test results, COA checklist.

We read 60 studies to write this report.
Get the report · $19 ↓
Safety

Safety. Side effects.

Safety · in the Kisspeptin-10 report

The watch-for list — contraindications, drug interactions, monitoring labs, when to stop.

Get the report · $19 ↓
Editorial Position

Editorial position.

Editorial Position · in the Kisspeptin-10 report

Our editorial position — explicit yes / no / depends, with the reasoning behind it.

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Citations

Citations.

  1. 01Navarro VM. Metabolic regulation of kisspeptin - the link between energy balance and reproduction. Nature reviews. Endocrinology. 2020;16(8):407-420. PMID: 32427949.
  2. 02Li Z, et al. Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src. Nature communications. 2024;15(1):1300. PMID: 38346942.
  3. 03Aguirre RS, et al. Central precocious puberty: From genetics to treatment. Best practice & research. Clinical endocrinology & metabolism. 2018;32(4):343-354. PMID: 30086862.
  4. 04Colpaert T, et al. Investigating the detection of the novel doping‐relevant peptide kisspeptin‐10 in urine using liquid chromatography high‐resolution mass spectrometry. Biomedical chromatography : BMC. 2024;38(9):e5946. PMID: 38978171.
  5. 05Radwańska P, et al. Kisspeptin-10 increases collagen content in the myocardium by focal adhesion kinase activity. Scientific reports. 2023;13(1):19977. PMID: 37968564.
+Show all 60 citations
  1. 06Roseweir AK, et al. Kisspeptin antagonists. Advances in experimental medicine and biology. 2013;784:159-86. PMID: 23550006.
  2. 07Colledge WH. GPR54 and kisspeptins. Results and problems in cell differentiation. 2008;46:117-43. PMID: 18193176.
  3. 08Simon C, et al. Kisspeptin-10 Mitigates α-Synuclein-Mediated Mitochondrial Apoptosis in SH-SY5Y-Derived Neurons via a Kisspeptin Receptor-Independent Manner. International journal of molecular sciences. 2023;24(7). PMID: 37047030.
  4. 09Fayyaz MH, et al. Kisspeptin-10 in cryodiluent improves the post-thaw quality of Nili-Ravi buffalo (Bubalus bubalis) bull spermatozoa. Andrologia. 2022;54(10):e14564. PMID: 36054451.
  5. 10Torres E, et al. Kisspeptin signaling in astrocytes modulates the reproductive axis. The Journal of clinical investigation. 2024;134(15). PMID: 38861336.
  6. 11Rizzo A, et al. Kisspeptin-10 and gonadotropin inhibiting hormone during pregnancy in dairy cows. Veterinaria italiana. 2022;58(1):111-116. PMID: 36398669.
  7. 12Curtis AE, et al. A kisspeptin-10 analog with greater in vivo bioactivity than kisspeptin-10. American journal of physiology. Endocrinology and metabolism. 2010;298(2):E296-303. PMID: 19934405.
  8. 13Guo L, et al. Kisspeptin-10 Promotes Progesterone Synthesis in Bovine Ovarian Granulosa Cells via Downregulation of microRNA-1246. Genes. 2022;13(2). PMID: 35205342.
  9. 14Loncová B, et al. Role of kisspeptin-10 and betacellulin in control of feline ovarian cell functions. Reproductive biology. 2023;23(2):100762. PMID: 37058773.
  10. 15Roosta Z, et al. Intraperitoneal administration of kisspeptin-10 modulates follicle maturation, gonadal steroids, calcium and metabolites in Sterlet sturgeon, Acipenser ruthenus. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 2024;292:111609. PMID: 38401763.
  11. 16Grattan DR, et al. Kisspeptin and Prolactin. Seminars in reproductive medicine. 2019;37(2):93-104. PMID: 31847029.
  12. 17Lu D, et al. Hypothalamic kisspeptin alleviates myasthenia gravis by regulating Th1/Th17/Treg balance through Inhibition of NF-κB signaling pathway. Journal of neuroinflammation. 2025;22(1):158. PMID: 40524201.
  13. 18Simon C, et al. Kisspeptin-10 Rescues Cholinergic Differentiated SHSY-5Y Cells from α-Synuclein-Induced Toxicity In Vitro. International journal of molecular sciences. 2022;23(9). PMID: 35563582.
  14. 19Qin YS, et al. Effects of kisspeptin-10 on the reproductive performance of sows in a fixed-time artificial insemination programme. Animal : an international journal of animal bioscience. 2022;16(5):100509. PMID: 35436648.
  15. 20Vannecke W, et al. Cross-Linking Furan-Modified Kisspeptin-10 to the KISS Receptor. ACS chemical biology. 2017;12(8):2191-2200. PMID: 28714670.
  16. 21Son HE, et al. Kisspeptin-10 (KP-10) stimulates osteoblast differentiation through GPR54-mediated regulation of BMP2 expression and activation. Scientific reports. 2018;8(1):2134. PMID: 29391507.
  17. 22Mashiko D, et al. Intraperitoneal administration of mouse kisspeptin-10 to mice during estrus stage induces pseudopregnancy. Genes to cells : devoted to molecular & cellular mechanisms. 2023;28(12):906-914. PMID: 37886801.
  18. 23Mills EGA, et al. Kisspeptin as a Behavioral Hormone. Seminars in reproductive medicine. 2019;37(2):56-63. PMID: 31847025.
  19. 24Seminara SB. Kisspeptin in reproduction. Seminars in reproductive medicine. 2007;25(5):337-43. PMID: 17710729.
  20. 25Herbison AE. Genetics of puberty. Hormone research. 2007;68 Suppl 5:75-9. PMID: 18174715.
  21. 26Orlando G, et al. Effects of Kisspeptin-10 on Hypothalamic Neuropeptides and Neurotransmitters Involved in Appetite Control. Molecules (Basel, Switzerland). 2018;23(12). PMID: 30477219.
  22. 27Sawyer I, et al. The vasoactive potential of kisspeptin-10 in the peripheral vasculature. PloS one. 2011;6(2):e14671. PMID: 21347414.
  23. 28Fatima I, et al. Intraperitoneal kisspeptin-10 administration ameliorates sodium arsenite-induced reproductive toxicity in adult male mice. Andrologia. 2022;54(3):e14347. PMID: 34897760.
  24. 29Tena-Sempere M, et al. Editorial. Peptides. 2009;30(1):1-3. PMID: 18771699.
  25. 30Stoynev N, et al. Kisspeptin system-physiology and clinical perspectives. Annales d'endocrinologie. 2025;86(4):101793. PMID: 40446957.
  26. 31Ludwig M, et al. Provocative tests with Kisspeptin-10 and GnRH set the scene for determining social status and environmental impacts on reproductive capacity in male African lions (Panthera leo). General and comparative endocrinology. 2022;329:114127. PMID: 36150474.
  27. 32Joy KP, et al. Kisspeptin control of hypothalamus-pituitary-ovarian functions. Vitamins and hormones. 2025;127:153-206. PMID: 39864941.
  28. 33Martino NA, et al. Effects of kisspeptin-10 on in vitro proliferation and kisspeptin receptor expression in primary epithelial cell cultures isolated from bovine placental cotyledons of fetuses at the first trimester of pregnancy. Theriogenology. 2015;83(6):978-987.e1. PMID: 25549944.
  29. 34Thompson EL, et al. Central and peripheral administration of kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis. Journal of neuroendocrinology. 2004;16(10):850-8. PMID: 15500545.
  30. 35Huma T, et al. Kisspeptin-10 treatment generated specific GnRH expression in cells differentiated from rhesus monkey derived Lyon NSCs. Neuroscience. 2017;349:318-329. PMID: 28288899.
  31. 36George JT, et al. Kisspeptin-10 stimulation of gonadotrophin secretion in women is modulated by sex steroid feedback. Human reproduction (Oxford, England). 2012;27(12):3552-9. PMID: 22956346.
  32. 37Leonardi CEP, et al. Effect of Kisspeptin-10 on plasma luteinizing hormone concentrations and follicular dynamics during the luteal phase in cattle. Theriogenology. 2018;119:268-274. PMID: 30071491.
  33. 38Trevisan CM, et al. Kisspeptin/GPR54 System: What Do We Know About Its Role in Human Reproduction?. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2018;49(4):1259-1276. PMID: 30205368.
  34. 39Schmidt E, et al. Kisspeptin-10 inhibits stromal-derived factor 1-induced invasion of human endometrial cancer cells. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 2014;24(2):210-7. PMID: 24407584.
  35. 40Jayasena CN, et al. The effects of kisspeptin-10 on reproductive hormone release show sexual dimorphism in humans. The Journal of clinical endocrinology and metabolism. 2011;96(12):E1963-72. PMID: 21976724.
  36. 41Ramzan F, et al. Dose-Dependent Degeneration of Leydig Cells Following Kisspeptin-10 Administration: An Ultrastructural Study. Protein and peptide letters. 2022;29(1):64-70. PMID: 34961438.
  37. 42Akkaya H, et al. What is the protective effect of preischemic kisspeptin-10 administration against ischemia/reperfusion injury of striatum on mice?. Turkish journal of medical sciences. 2022;52(5):1532-1542. PMID: 36422497.
  38. 43George JT, et al. Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men. The Journal of clinical endocrinology and metabolism. 2011;96(8):E1228-36. PMID: 21632807.
  39. 44Olbrich T, et al. Kisspeptin-10 inhibits bone-directed migration of GPR54-positive breast cancer cells: Evidence for a dose-window effect. Gynecologic oncology. 2010;119(3):571-8. PMID: 20832102.
  40. 45Jayasena CN, et al. Direct comparison of the effects of intravenous kisspeptin-10, kisspeptin-54 and GnRH on gonadotrophin secretion in healthy men. Human reproduction (Oxford, England). 2015;30(8):1934-41. PMID: 26089302.
  41. 46Roseweir AK, et al. Kisspeptin-10 inhibits cell migration in vitro via a receptor-GSK3 beta-FAK feedback loop in HTR8SVneo cells. Placenta. 2012;33(5):408-15. PMID: 22349353.
  42. 47Santos LC, et al. Kisspeptin-10 Improves Testicular Redox Status but Does Not Alter the Unfolded Protein Response (UPR) That Is Downregulated by Hypothyroidism in a Rat Model. International journal of molecular sciences. 2024;25(3). PMID: 38338793.
  43. 48Ziyaraa MA, et al. Correlation of Kisspeptin-10 level and fetal well-being in preeclamptic patients. Taiwanese journal of obstetrics & gynecology. 2016;55(6):840-846. PMID: 28040130.
  44. 49Pruszyńska-Oszmałek E, et al. Kisspeptin-10 inhibits proliferation and regulates lipolysis and lipogenesis processes in 3T3-L1 cells and isolated rat adipocytes. Endocrine. 2017;56(1):54-64. PMID: 28194651.
  45. 50Mills EGA, et al. The Roles of the Amygdala Kisspeptin System. Seminars in reproductive medicine. 2019;37(2):64-70. PMID: 31847026.
  46. 51Guzman S, et al. KISS1/KISS1R and Breast Cancer: Metastasis Promoter. Seminars in reproductive medicine. 2019;37(4):197-206. PMID: 31972865.
  47. 52Usui S, et al. Kisspeptin-10 induces endothelial cellular senescence and impaired endothelial cell growth. Clinical science (London, England : 1979). 2014;127(1):47-55. PMID: 24405415.
  48. 53Avendaño MS, et al. The evolutionary conserved miR-137/325 tandem mediates obesity-induced hypogonadism and metabolic comorbidities by repressing hypothalamic kisspeptin. Metabolism: clinical and experimental. 2024;157:155932. PMID: 38729600.
  49. 54Hellier V, et al. The Role of Kisspeptin in Sexual Behavior. Seminars in reproductive medicine. 2019;37(2):84-92. PMID: 31847028.
  50. 55Hameed S, et al. Kisspeptin and fertility. The Journal of endocrinology. 2011;208(2):97-105. PMID: 21084385.
  51. 56Sato K, et al. Potent Vasoconstrictor Kisspeptin-10 Induces Atherosclerotic Plaque Progression and Instability: Reversal by its Receptor GPR54 Antagonist. Journal of the American Heart Association. 2017;6(4). PMID: 28411243.
  52. 57Kadokawa H, et al. Kisspeptin-10 stimulates the secretion of growth hormone and prolactin directly from cultured bovine anterior pituitary cells. Animal reproduction science. 2008;105(3-4):404-8. PMID: 18096333.
  53. 58Suzuki S, et al. Direct kisspeptin-10 stimulation on luteinizing hormone secretion from bovine and porcine anterior pituitary cells. Animal reproduction science. 2008;103(3-4):360-5. PMID: 17604578.
  54. 59Roseweir AK, et al. Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009;29(12):3920-9. PMID: 19321788.
  55. 60Cao Y, et al. Kisspeptin-10 Maintains the Activation of the mTOR Signaling Pathway by Inhibiting SIRT6 to Promote the Synthesis of Milk in Bovine Mammary Epithelial Cells. Journal of agricultural and food chemistry. 2021;69(14):4093-4100. PMID: 33818062.
The Kisspeptin-10 Report · $19

Everything you need to start.

Dose, sourcing, safety, our verdict. One purchase. Yours forever.

Built from 60 cited studies.

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