Library/For Wet/HMG

FDA-approvedFor WetFertility · LH+FSHIVF standard+2 more

HMG

Menotropin. We read all 60 studies. The protocol is below.

Updated 03 May 2026Read 12 minEvidence ●●●●●Citations 60

+ Add to Stack⚖ Compare

⚖ Compare side-by-side ⎙ Print companion card

Free — puts HMG on your decision board.

The HMG Report · $19

Everything you need to start: dose, sourcing, safety, our verdict.

One purchase · yours forever

Built from 60 cited studies.

Status

FDA

Class

For Wet

Evidence

5/ 5●●●●●

FDA-approved

$19 ↓

Years in clinical use

$19 ↓

IVF standard

$19 ↓

Read this if

you're on TRT, you've been on it long enough that hCG isn't restoring sperm, and you want kids
you're going through IVF and Menopur is on your protocol
you ran a long anabolic cycle and need the FSH side that hCG alone won't give you

Skip this if

you want a libido or "boost" peptide — this isn't one
you have hormone-sensitive cancer or undiagnosed adnexal masses
you can't reliably inject several times a week and follow a stim protocol
**you're looking at an 'RUO hMG' vial** — walk. hMG is an FDA-approved injectable; the legitimate products are Menopur (Ferring) and Repronex. The molecule is purified from postmenopausal urine at industrial scale — not a synthesis route research-chemical vendors can replicate. 'RUO hMG' is essentially never the real product

The 4 ways you can buy HMG

Few pharmacies compound hMG — harder than hCG due to FSH/LH mix.

RUO (research-only)

✓

Sold for research only

$120–$180/mo (if it were real product — which it almost never is)

The molecule is purified from postmenopausal urine at industrial scale — not a synthesis route res…

Gray market

✓

Illegal to import for huma…

$85–$100/mo

No meaningful gray-market — hMG synthesis isn't a gray-favored route.

Click any lane for the full Sourcing breakdown. Prices and lane availability vary by molecule — this is the per-peptide snapshot, not a generic table.

First 90 days · HMG

What we'd actually do

Weeks 1–2

On-demand class — works in 30–60 min on the day of use or it doesn't. The PT-141 effect either shows up at the proper dose or it's the wrong molecule for you.

Weeks 4–8

Side-effect accumulation is the real watch-for: facial hyperpigmentation (MC1 receptor), nausea with repeated use, mood changes.

Week 12 — decide

Decide based on the on-demand response pattern, not a slow build-up. There is no slow build-up here.

Quit if

Facial or scalp hyperpigmentation that doesn't fade after stopping for 2–4 weeks.
Persistent nausea on repeated use.
Zero response to 2–3 attempts at proper dose (one of these — it's not for everyone).

Identity

What it is.

hMG is human menopausal gonadotropin — a preparation containing both FSH (follicle-stimulating hormone) and LH (luteinizing hormone) in roughly equal proportions. Originally extracted from the urine of post-menopausal women (Menopur, Menogon, Pergonal), where FSH and LH are naturally elevated due to the loss of ovarian feedback. Recombinant versions and purified urinary versions also exist.

It's for female infertility — specifically for stimulating multiple follicle development in women undergoing IVF or other assisted reproduction protocols. It's also approved for inducing spermatogenesis in men with hypogonadotropic hypogonadism, usually after an initial period of hCG to elevate intratesticular testosterone.

In the men's health and TRT-fertility world, hMG is used alongside hCG to restore or maintain sperm production. The combination matters — hCG handles the LH side, hMG provides the FSH side that hCG alone doesn't cover.

TL;DR

TL;DR. 30-second version.

The compressed verdict — what HMG actually is, what the human evidence shows, and the watch-for in three bullets. Locked.

Get the report · $19 ↓

Mechanism

Mechanism.

Mechanism · in the HMG report

How the molecule actually works — receptor profile, downstream signaling, what to expect mechanistically.

Get the report · $19 ↓

Evidence

Evidence. What we actually know in humans.

Evidence · in the HMG report

The trial breakdown — phase, n, primary endpoint, who funded, what hit, what didn't.

Get the report · $19 ↓

Human-Evidence Factbox

FDA-approved

$19 ↓

Years in clinical use

IVF standard

Provides

Brand names

Sperm-induction rate — hCG alone (HH men)

$19 ↓

Sperm-induction rate — hCG + hMG/rFSH

$19 ↓

When to add hMG to hCG

$19 ↓

Sourcing red flag — 'RUO hMG'

$19 ↓

Cost reconciled

$19 ↓

Major adverse events flagged

$19 ↓

Dose

Dose. The actual protocol.

Dose · in the HMG report

The specific protocol — dose, titration schedule, cycle pattern, frequency, route.

We read 60 studies to write this report.

Get the report · $19 ↓

Sourcing

Sourcing. Where the cohort actually buys.

Sourcing · in the HMG report

Sourcing breakdown — vendor methodology, red flags, our published test results, COA checklist.

We read 60 studies to write this report.

Get the report · $19 ↓

Safety

Safety. Side effects.

Safety · in the HMG report

The watch-for list — contraindications, drug interactions, monitoring labs, when to stop.

Get the report · $19 ↓

Editorial Position

Editorial position.

Editorial Position · in the HMG report

Our editorial position — explicit yes / no / depends, with the reasoning behind it.

Get the report · $19 ↓

Citations

Citations.

+Show all 60 citations

The HMG Report · $19

Everything you need to start.

Dose, sourcing, safety, our verdict. One purchase. Yours forever.

Built from 60 cited studies.

Or get every report. All reports — $99 once · Pro — $29/mo.

Compare tiers →