Growth hormone secretagogues are compounds that signal the pituitary to release GH. Two families: GHRH analogs (CJC-1295, sermorelin, tesamorelin) which mimic the natural GHRH signal, and ghrelin mimetics (ipamorelin, GHRP-2, GHRP-6, hexarelin, MK-677) which activate the GHS-receptor. GHS produces pulsatile GH release that more closely resembles natural patterns than direct injection of recombinant HGH. Most GHS dose at night to align with natural GH pulse timing.
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