yes i take peptides · shopping companion

VIP (Vasoactive Intestinal Peptide)

Aviptadil / Zyesami / RLF-100

Category · For EnergyStatus · FDACitations · 60

The verdict

Depends — VIP has a real clinical program (aviptadil/Zyesami/RLF-100 in ARDS and pulmonary hypertension) but the off-label intranasal use the gray market sells — for CIRS, Lyme, mold illness — has thin controlled evidence and a non-trivial cardiovascular and mast-cell safety profile.

By source — cost, legality, risk

FDA-approved brand (aviptadil — narrow)
Specialist-billed (no standard cash price)
Rx, narrow indication only
Lowest in approved indication. Not a primary-care offering.
Compounded 503A (CIRS nasal spray — Shoemaker network)
$200–$500/mo
Off-label compounded
Mid. 'CIRS' indication is not validated by controlled trials; small specialty network.
RUO research-chemical site
$80–$200/mo
Sold for research only
Highest. VIP degrades quickly; identity and stability unverified.
Gray-market overseas raw
$5–$8/mo at 100mcg/d
Illegal to import for human use
Highest. Small gray market; VIP stability is a real concern for any non-cold-chain shipment.

Sources · top 5 of 60

01Said SI. Vasoactive intestinal peptide. Journal of endocrinological investigation. 1986;9(2):191-200. PMID: 2872248.
02Youssef JG, et al. The Use of IV Vasoactive Intestinal Peptide (Aviptadil) in Patients With Critical COVID-19 Respiratory Failure: Results of a 60-Day Randomized Controlled Trial. Critical care medicine. 2022;50(11):1545-1554. PMID: 36044317.
03Hou X, et al. Therapeutic potential of vasoactive intestinal peptide and its receptor VPAC2 in type 2 diabetes. Frontiers in endocrinology. 2022;13:984198. PMID: 36204104.
04Foster N. Editorial: vasoactive intestinal peptide (vip): historic perspective and future potential. Endocrine, metabolic & immune disorders drug targets. 2012;12(4):303-7. PMID: 23094826.
05Iwasaki M, et al. Recent advances in vasoactive intestinal peptide physiology and pathophysiology: focus on the gastrointestinal system. F1000Research. 2019;8. PMID: 31559013.