yes i take peptides · shopping companion

Tirzepatide

Mounjaro / Zepbound

Category · For Weight LossStatus · FDACitations · 60MTC Black Box

The verdict

Dual GIP and GLP-1 receptor agonist. The biggest weight-loss number ever recorded in a phase 3 trial — about 22.5% body weight at 72 weeks on the top dose.

By source — cost, legality, risk

Brand — Mounjaro / Zepbound
$300–$1,100/mo (LillyDirect cash to retail list)
FDA-approved · prescription
Lowest. Real pharmacy product; LillyDirect single-dose vials drop cash to $299–$449.
Compounded 503A pharmacy
$179–$499/mo
Prescription · supply collapsing post-shortage
Mid. Pharmacy-grade — but most large compounders were shut by Lilly's 2025 lawsuits.
RUO research peptide
$60–$200/mo
Sold 'for research only'
Highest. No purity guarantee — you reconstitute it yourself.
Gray-market raw
$10–$50/mo
Unregulated overseas import
Crypto/Wise pay, no published COA; cheaper per mg than RUO at larger box sizes.

Sources · top 5 of 60

01Aronne LJ, et al. Continued Treatment With Tirzepatide for Maintenance of Weight Reduction in Adults With Obesity: The SURMOUNT-4 Randomized Clinical Trial. JAMA. 2024;331(1):38-48. PMID: 38078870.
02Frías JP, et al. Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes. The New England journal of medicine. 2021;385(6):503-515. PMID: 34170647.
03Jastreboff AM, et al. Tirzepatide for Obesity Treatment and Diabetes Prevention. The New England journal of medicine. 2025;392(10):958-971. PMID: 39536238.
04Garvey WT, et al. Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial. Lancet (London, England). 2023;402(10402):613-626. PMID: 37385275.
05Zhao L, et al. Tirzepatide for Weight Reduction in Chinese Adults With Obesity: The SURMOUNT-CN Randomized Clinical Trial. JAMA. 2024;332(7):551-560. PMID: 38819983.