yes i take peptides · shopping companion

Sermorelin

Category · For EnergyStatus · RXCitations · 60WADA-banned · IGF-1 Elevation

The verdict

Depends — sermorelin has the cleanest GH-secretagogue safety profile but the FDA pulled it from the US market for commercial reasons in 2008, and the current supply is compounded or RUO with all the supply-side instability that implies.

By source — cost, legality, risk

Brand — Geref (discontinued)
Not available
None active — Geref discontinued 2008 for commercial reasons
No current FDA-approved sermorelin brand; the dominant clinical channel is compounded.
Compounded 503A pharmacy
$150–$400/mo
Rx · the dominant clinical channel
Lowest. Pharmacy-grade; sermorelin has the longest clinical-use history of the GH-secretagogue family.
RUO research peptide
$30–$100/mo
Sold 'for research only'
Highest. The cheap-fallback; identity-failures vs CJC-1295 or Mod GRF 1-29 are documented.
Gray-market raw
$10–$25/mo
Unregulated overseas import
Same upstream synthesis as RUO. Crypto/Wise pay; one box covers many months.

Sources · top 5 of 60

01Rahman OF, et al. Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions. Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews. 2026;10(1). PMID: 41490200.
02Walker RF. Sermorelin: a better approach to management of adult-onset growth hormone insufficiency?. Clinical interventions in aging. 2006;1(4):307-8. PMID: 18046908.
03Memdouh S, et al. Advances in the detection of growth hormone releasing hormone synthetic analogs. Drug testing and analysis. 2021;13(11-12):1871-1887. PMID: 34665524.
04Chang Y, et al. A potentially effective drug for patients with recurrent glioma: sermorelin. Annals of translational medicine. 2021;9(5):406. PMID: 33842627.
05Prakash A, et al. Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. 1999;12(2):139-57. PMID: 18031173.