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Retatrutide

Category · For Weight LossStatus · RUOCitations · 60Heart Rate +7 bpm

The verdict

GLP-1 plus GIP plus glucagon. The phase 2 trial put up a 24.2% weight loss at 48 weeks — bigger than tirzepatide at the same time point. **Phase 3 (TRIUMPH) is still running.** No FDA approval. The only form you can actually buy today is RUO powder you reconstitute yourself.

By source — cost, legality, risk

Brand
Not available
None — in Lilly's Phase 3 pipeline, FDA submission expected late 2026
No FDA-approved retatrutide exists yet.
Compounded 503A pharmacy
$200–$600/mo
Not on the FDA bulks list · FDA warning letters issued Mar 2026
High. Legally contested — the pharmacies selling it are under FDA pressure.
RUO research peptide
$120–$280/mo
Sold 'for research only'
Highest. The dominant supply; the triple agonist is hard to synthesize cleanly, sub-95% purity is common.
Gray-market raw
$10–$70/mo
Unregulated overseas import
Growing as compounders exit; identity failures (powder is actually tirzepatide) are documented.

Sources · top 5 of 60

01Jastreboff AM, et al. Triple-Hormone-Receptor Agonist Retatrutide for Obesity - A Phase 2 Trial. The New England journal of medicine. 2023;389(6):514-526. PMID: 37366315.
02Katsi V, et al. Retatrutide-A Game Changer in Obesity Pharmacotherapy. Biomolecules. 2025;15(6). PMID: 40563436.
03Abdul-Rahman T, et al. The power of three: Retatrutide's role in modern obesity and diabetes therapy. European journal of pharmacology. 2024;985:177095. PMID: 39515565.
04Rosenstock J, et al. Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA. Lancet (London, England). 2023;402(10401):529-544. PMID: 37385280.
05Sanyal AJ, et al. Triple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease: a randomized phase 2a trial. Nature medicine. 2024;30(7):2037-2048. PMID: 38858523.