yes i take peptides · shopping companion

Larazotide

AT-1001

Category · For RecoveryStatus · RUOCitations · 60

The verdict

No for off-label "leaky gut" use. Depends — at best — for biopsy-confirmed celiac with persistent symptoms on a strict gluten-free diet, under a gastroenterologist, with the CeDLara phase 3 failure on the table.

By source — cost, legality, risk

Brand
Not available
None — phase 3 failed in 2022, program discontinued
No FDA-approved larazotide; sponsor has exited.
Compounded 503A pharmacy
$200–$400/mo where sold
Off-label · no FDA approval, no bulks list path
Mid–high. Some compounders carry; legally exposed since indication ('leaky gut') has no validated human trial.
RUO research peptide
$60–$150/mo
Sold 'for research only'
Highest. Oral peptide is degraded by gut proteases — RUO 'larazotide' powder is hard to dose orally without enteric coating.
Gray-market raw
Varies — not on user's vendor list
Unregulated overseas import
Available via overseas raws but oral peptide without enteric coating is functionally useless — gray-market larazotide rarely makes economic sense.

Sources · top 5 of 60

01Yang X, et al. Targeting endothelial tight junctions to predict and protect thoracic aortic aneurysm and dissection. European heart journal. 2023;44(14):1248-1261. PMID: 36638776.
02Troisi J, et al. The Therapeutic use of the Zonulin Inhibitor AT-1001 (Larazotide) for a Variety of Acute and Chronic Inflammatory Diseases. Current medicinal chemistry. 2021;28(28):5788-5807. PMID: 33397225.
03Tajik N, et al. Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis. Nature communications. 2020;11(1):1995. PMID: 32332732.
04Veres-Székely A, et al. Zonulin as a Potential Therapeutic Target in Microbiota-Gut-Brain Axis Disorders: Encouraging Results and Emerging Questions. International journal of molecular sciences. 2023;24(8). PMID: 37108711.
05Damianos JA, et al. Coeliac disease and the intestinal barrier: mechanisms of disruption and strategies for restoration. Gut. 2026;75(4):826-838. PMID: 40579122.