yes i take peptides · shopping companion

Humanin

Category · For LongStatus · RUOCitations · 60

The verdict

Mostly no — humanin is genuinely interesting biology with almost no controlled human evidence and an anti-apoptotic mechanism that puts oncology surveillance on the table.

By source — cost, legality, risk

Brand
Not available
None — no FDA approval; no clinical-stage development
No FDA-approved humanin exists.
Compounded 503A pharmacy
$200–$400/mo where sold
Off-label · not on bulks list
Mid–high. Few compounders carry; zero human trials means clinical legitimacy is weak.
RUO research peptide
$80–$200/mo
Sold 'for research only'
Highest. The dominant supply; 24-residue peptide is moderately difficult to synthesize, identity-failures are common at the cheap tier.
Gray-market raw
Varies — not on user's vendor list
Unregulated overseas import
Available via overseas raws but humanin's research-only status means most gray vendors don't stock it; supply is intermittent.

Sources · top 5 of 60

01Coradduzza D, et al. Humanin and Its Pathophysiological Roles in Aging: A Systematic Review. Biology. 2023;12(4). PMID: 37106758.
02Lei H, et al. The role of humanin in the regulation of reproduction. Biochimica et biophysica acta. General subjects. 2022;1866(1):130023. PMID: 34626748.
03Niikura T. Humanin and Alzheimer's disease: The beginning of a new field. Biochimica et biophysica acta. General subjects. 2022;1866(1):130024. PMID: 34626746.
04Xiao J, et al. Humanin: Functional Interfaces with IGF-I. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. 2016;29:21-27. PMID: 27082450.
05Hazafa A, et al. Humanin: A mitochondrial-derived peptide in the treatment of apoptosis-related diseases. Life sciences. 2021;264:118679. PMID: 33130077.