yes i take peptides · shopping companion

Glutathione

Category · For LongStatus · OTCCitations · 60

The verdict

A tripeptide your liver makes. The body's main intracellular antioxidant. Oral absorption is poor; liposomal forms work better. IV pushes blood levels fast but for short windows.

By source — cost, legality, risk

Brand
Not available
None — no FDA-approved branded systemic glutathione drug for healthy adults
No drug-grade brand; OTC liposomal supplements and clinic IV are the realistic channels.
Compounded 503A pharmacy (IV / subq)
$120–$1,000/mo (subq to IV-bar pricing)
Rx · IV bars and tele-clinics
Mid. Pharmacy-grade; IV-bar markup is the cost driver, not the molecule.
RUO research peptide
$40–$150/mo (oral/liposomal) or $50–$200/mo (RUO injectable)
Sold 'for research only'
Highest for injectable form. OTC liposomal is the safer cheap path.
Gray-market raw
$10–$15/mo at IV-dose volumes
Unregulated overseas import
Crypto/Wise pay; glutathione oxidizes in solution, so reconstituted product older than ~14 days is sub-potent.

Sources · top 5 of 60

01Oestreicher J, et al. Glutathione: subcellular distribution and membrane transport (1). Biochemistry and cell biology = Biochimie et biologie cellulaire. 2019;97(3):270-289. PMID: 30427707.
02Gnanasekaran P, et al. Detection of Protein-Protein Interactions Using Glutathione-S-Transferase (GST) Pull-Down Assay Technique. Methods in molecular biology (Clifton, N.J.). 2023;2690:111-115. PMID: 37450141.
03Dong SC, et al. Glutathione S-transferase π: a potential role in antitumor therapy. Drug design, development and therapy. 2018;12:3535-3547. PMID: 30425455.
04Niitsu Y, et al. Implications of glutathione-S transferase P1 in MAPK signaling as a CRAF chaperone: In memory of Dr. Irving Listowsky. Proceedings of the Japan Academy. Series B, Physical and biological sciences. 2022;98(2):72-86. PMID: 35153270.
05Boyland E, et al. Glutathione S-aralkyltransferase. The Biochemical journal. 1969;115(5):985-91. PMID: 5360727.