yes i take peptides · shopping companion
FOXO4-DRI
Category · For LongStatus · RUOCitations · 17One-paper compound
The verdict
No — and this is one of the few peptides on this site we'd actively recommend against.
By source — cost, legality, risk
- BrandNot availableNone — no FDA approval; no clinical-stage developmentNo FDA-approved FOXO4-DRI exists.
- Compounded 503A pharmacy$400–$800/mo where soldOff-label · cytotoxic mechanism, most compounders declineHigh. Compounders shipping a deliberately-cytotoxic peptide pre-trial are legally and ethically exposed.
- RUO research peptide$150–$400/moSold 'for research only'Highest. D-retro-inverso synthesis is hard, sub-90% purity is common; identity by mass spec alone is insufficient.
- Gray-market raw~$38/moUnregulated overseas importCrypto/Wise pay; D-retro-inverso stereochemistry verification is even harder for gray vendors than for RUO.
Stop signals · abort if
- persistent fevers > 48 hours
- new bruising or bleeding
- jaundice or RUQ pain
- chest pain or shortness of breath
- any new mass or unexplained pain
- severe or worsening "flu-like" reaction
Sources · top 5 of 17
- 01Born E, et al. Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression. Circulation. 2023;147(8):650-666. PMID: 36515093.
- 02Liu Y, et al. FOXO4-D-Retro-Inverso targets extracellular matrix production in fibroblasts and ameliorates bleomycin-induced pulmonary fibrosis in mice. Naunyn-Schmiedeberg's archives of pharmacology. 2023;396(10):2393-2403. PMID: 37074394.
- 03Meng J, et al. Targeting senescence-like fibroblasts radiosensitizes non-small cell lung cancer and reduces radiation-induced pulmonary fibrosis. JCI insight. 2021;6(23). PMID: 34877934.
- 04Bourgeois B, et al. The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI. Nature communications. 2025;16(1):5672. PMID: 40593617.
- 05Kong YX, et al. FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation. Communications biology. 2025;8(1):299. PMID: 39994346.