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Enclomiphene

Category · For WetStatus · RXCitations · 60

The verdict

Yes — for men with documented secondary hypogonadism who want to preserve fertility, prescribed by a men's-health clinician who monitors testosterone, LH/FSH, estradiol, PSA, hematocrit, visual symptoms, and mood. Not appropriate as a casual "test-boost" for men with normal HPG axis, and not appropriate self-directed from gray-market supply.

By source — cost, legality, risk

FDA-approved brand
Not available
None — no FDA approval (Androxal NDA rejected 2016)
No US brand. Racemic clomiphene (Clomid) is a different drug.
Compounded 503A
$50–$90/mo
Off-label Rx
Lowest. Dominant channel; widely stocked.
RUO research-chemical site
$30–$60/mo
Sold for research only
Highest. Smaller channel — compounded is too cheap for gray to gain traction.
Gray-market overseas raw
Varies — not on user's vendor list
Illegal to import for human use
Unverified. No meaningful gray market for enclomiphene — compounded pathway is too inexpensive.

Sources · top 5 of 60

01Saffati G, et al. Safety and efficacy of enclomiphene and clomiphene for hypogonadal men. Translational andrology and urology. 2024;13(9):1984-1990. PMID: 39434750.
02Rodriguez KM, et al. Enclomiphene citrate for the treatment of secondary male hypogonadism. Expert opinion on pharmacotherapy. 2016;17(11):1561-7. PMID: 27337642.
03Thomas J, et al. Efficacy of Clomiphene Citrate Versus Enclomiphene Citrate for Male Infertility Treatment: A Retrospective Study. Cureus. 2023;15(7):e41476. PMID: 37546076.
04Hill S, et al. Enclomiphene, an estrogen receptor antagonist for the treatment of testosterone deficiency in men. IDrugs : the investigational drugs journal. 2009;12(2):109-19. PMID: 19204885.
05Hohl A, et al. Clomiphene or enclomiphene citrate for the treatment of male hypogonadism: a systematic review and meta-analysis of randomized controlled trials. Archives of endocrinology and metabolism. 2025;69(5). PMID: 41066380.