yes i take peptides · shopping companion

Dihexa

N-hexanoic-Tyr-Ile-(6) aminohexanoic amide

Category · For CognitionStatus · RUOCitations · 17

The verdict

No — the foundational dihexa biochemistry was formally retracted in 2025, there is no published human Phase 1 trial, and the proposed mechanism of action overlaps directly with one of the most-validated tumor-promotion pathways in oncology.

By source — cost, legality, risk

Brand
Not available
None — no FDA approval; no clinicaltrials.gov entry
No FDA-approved Dihexa exists.
Compounded 503A pharmacy
Not meaningfully available
Off-label · not on FDA bulks list, no legitimate 503A path
Zero human trials means no compounder has a legitimate prescribing-indication backing.
RUO research peptide
$50–$140/mo
Sold 'for research only'
Highest. Identity-verification problems are documented (community SARMs-style purity tests often find no Dihexa in the vial).
Gray-market raw
Varies — not on user's vendor list
Unregulated overseas import
Available via Chinese chem suppliers but identity verification is essentially impossible without LC-MS — most powders sold as 'Dihexa' fail community purity tests.

Sources · top 5 of 17

01Rahman OF, et al. Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions. Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews. 2026;10(1). PMID: 41490200.
02Wells RG, et al. Effects of an Angiotensin IV Analog on 3-Nitropropionic Acid-Induced Huntington's Disease-Like Symptoms in Rats. Journal of Huntington's disease. 2024;13(1):55-66. PMID: 38489193.
03Uribe PM, et al. Hepatocyte growth factor mimetic protects lateral line hair cells from aminoglycoside exposure. Frontiers in cellular neuroscience. 2015;9:3. PMID: 25674052.
04Weiss JB, et al. Stem cell, Granulocyte-Colony Stimulating Factor and/or Dihexa to promote limb function recovery in a rat sciatic nerve damage-repair model: Experimental animal studies. Annals of medicine and surgery (2012). 2021;71:102917. PMID: 34703584.
05Bapst JP, et al. Dimeric DOTA-alpha-melanocyte-stimulating hormone analogs: synthesis and in vivo characteristics of radiopeptides with high in vitro activity. Journal of receptor and signal transduction research. 2007;27(5-6):383-409. PMID: 18097939.