yes i take peptides · shopping companion
5-Amino-1MQ
Category · For LongStatus · RUOCitations · 4
The verdict
Depends — and only for a narrow population willing to treat it as a 12-week experiment with hard before/after labs.
By source — cost, legality, risk
- BrandNot availableNone — no FDA approvalNo FDA-approved 5-amino-1MQ.
- Compounded 503A pharmacy (incl. longevity clinics, $320–$500 dispensed)$180–$500/moRx requiredLowest commercial path; longevity-clinic markup is the spread.
- RUO research peptide$60–$110/moSold for research onlyHighest. Purity varies; the molecule is a small-molecule inhibitor, not a peptide — synthesis is straightforward but identity by mass spec is the only check.
- Gray-market rawVaries — not on user's gray-vendor list 2026Unregulated overseas importUnverified. No meaningful gray market for 5-amino-1MQ — it's a niche research chemical, not a commodity peptide.
Stop signals · abort if
- jaundice, dark urine, or RUQ pain (hepatic signal)
- persistent severe nausea or vomiting
- new neuropathic symptoms (paresthesias, numbness
- methylation-flux concern)
- any unexplained bleeding or bruising
Sources · top 4 of 4
- 01Yang M, et al. NAD(+) metabolism enzyme NNMT in cancer-associated fibroblasts drives tumor progression and resistance to immunotherapy by modulating macrophages in urothelial bladder cancer. Journal for immunotherapy of cancer. 2024;12(7). PMID: 39067875.
- 02Campagna R, et al. Nicotinamide N-methyltransferase in endothelium protects against oxidant stress-induced endothelial injury. Biochimica et biophysica acta. Molecular cell research. 2021;1868(10):119082. PMID: 34153425.
- 03Akar S, et al. Small molecule inhibitor of nicotinamide N-methyltransferase shows anti-proliferative activity in HeLa cells. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. 2021;41(8):1240-1245. PMID: 33645410.
- 04Dimet-Wiley A, et al. Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice. Scientific reports. 2022;12(1):484. PMID: 35013352.